Mile markers after breast cancer

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CA is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA in the assessment of patients with breast cancer without metastasis has not been substantiated yet. From February for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Following a diagnosis of breast cancer, the most immediate challenges in patient management are the determination of prognosis and the identification of the most appropriate neoadjuvant and adjuvant systemic therapy. Indicators to assess the risk of relapse or metastasis during treatment are still largely insufficient, a situation which does not allow to precisely adjust the treatment, often leading to heavy side effects.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. To assess whether patients with HER-2 negative, hormone receptor positive, metastatic breast cancer who are monitored with serum tumor marker directed disease monitoring STMDDM have non-inferior overall survival compared to patients monitored with usual care. To compare cumulative direct healthcare costs through 48 weeks among patients monitored with STMDDM versus those monitored with usual care in this patient population.

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Tamoxifen is one of the most effective treatments for breast cancer. Standard practice is to select patients who are likely to respond to this therapy through the evaluation of estrogen receptor ER and progesterone receptor PR in the primary tumor tissue. Over the past 25 yr that physicians have been using ER determination to guide tamoxifen use, numerous studies have demonstrated that this molecular marker is useful in predicting benefit from tamoxifen. ER has been analyzed for many years using ligand-binding assays.

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Skip to Content. To help doctors provide their patients with the highest quality care, the American Society of Clinical Oncology ASCO developed a new guideline on using biomarkers to guide the treatment of metastatic breast cancer. A biomarker is a substance that is found in the blood, urine, or body tissues of a person with cancer.

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Cancer antigen 15—3 CA is widely utilized for monitoring metastatic breast cancer BC. However, its utility for early detection of breast cancer is severely limited due to poor clinical sensitivity and specificity. The glycosylation of CA is known to be affected by BC, and therefore it might offer a way to construct CA glycovariant assays with improved cancer specificity.

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Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a positive impact on recognition and screening of breast cancer. Breast cancer is life-threatening disease in females and the leading cause of mortality among women population.

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Skip to Content. Tumor markers, also called serum markers or biomarkers, are substances found at higher than normal levels in the blood, urine, or body tissues of some people with cancer. In specific situations, biomarker tests can be used for many reasons, including to screen healthy people who have no symptoms of cancer, help diagnose several different types of cancer, determine the prognosis for a person with cancer, monitor how well cancer treatment is working, and watch for a recurrence cancer that has come back after treatment. However, many tumor markers can be at higher than normal levels in people without cancer, or a person with cancer could have low levels of tumor markers.

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Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor HR -positive breast cancer. Although estradiol is produced mainly by the ovary in premenopausal women, the adrenal gland and adipocytes are also sources of lesser amounts of estradiol 123. Therefore, obesity, a medical condition with excess adipose tissue, has been explored as a risk factor and prognosis marker for a poor outcome in patients with HR-positive breast cancer.

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Pathology reports are written in medical language because they are prepared for health care providers. This can make some of the wording hard to understand. However, understanding the basic parts of the report can help you be better informed about your diagnosis.

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